前额叶β事件特征与成人早期生活压力和精神症状有关

避免过度的精神压力，可以减轻帕金森症状。 #生活知识# #科技生活# #健康生活技巧# #帕金森氏症#

前额叶β事件特征与成人早期生活压力和精神症状有关

Brian C. Kavanaugh , Megan M. Vigne , Eric Tirrell , W. Luke Acuff , Andrew M. Fukuda , Ryan Thorpe , Anna Sherman , Stephanie R. Jones , Linda L. Carpenter , Audrey R. Tyrka

摘要

最近的研究发现，与传统的脑电图（EEG）功率指标相比，瞬时振荡猝发样事件的存在，尤其是β波段（15-29赫兹）内的瞬时振荡猝发样事件，与不同物种的疾病状态和行为关系更为密切。本研究试图探讨额顶电极上的β事件特征是否与早期生活压力（ELS）及相关临床表现有关。18 名有 ELS 记录的成年人（n = 18；ELS + ）和 18 名没有 ELS 记录的成年人（n = 18；ELS-）完成了闭眼静息状态脑电图，作为他们参与更大规模的儿童压力研究的一部分。在五个额顶电极上计算了β波段内瞬态振荡事件的速率、功率、持续时间和频率跨度。ELS变量与Fp2处的β事件速率和Pz处的β事件持续时间呈正相关，即ELS越大，静息速率越高，持续时间越长。这些β事件特征被用来成功区分 ELS + 组和 ELS- 组。在一个独立的临床数据集中（n = 25），Pz 处的β事件功率与 ELS 呈正相关。贝塔事件作为 ELS 和后续精神治疗结果的潜在疾病标志物，值得继续研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Frontoparietal beta event characteristics are associated with early life stress and psychiatric symptoms in adults

Recent work has found that the presence of transient, oscillatory burst-like events, particularly within the beta band (15–29 Hz), is more closely tied to disease state and behavior across species than traditional electroencephalography (EEG) power metrics. This study sought to examine whether features of beta events over frontoparietal electrodes were associated with early life stress (ELS) and the related clinical presentation. Eighteen adults with documented ELS (n = 18; ELS + ) and eighteen adults without documented ELS (n = 18; ELS-) completed eyes-closed resting state EEG as part of their participation in a larger childhood stress study. The rate, power, duration, and frequency span of transient oscillatory events were calculated within the beta band at five frontoparietal electrodes. ELS variables were positively associated with beta event rate at Fp2 and beta event duration at Pz, in that greater ELS was associated with higher resting rates and longer durations. These beta event characteristics were used to successfully distinguish between ELS + and ELS- groups. In an independent clinical dataset (n = 25), beta event power at Pz was positively correlated with ELS. Beta events deserve ongoing investigation as a potential disease marker of ELS and subsequent psychiatric treatment outcomes.

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期刊介绍： Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.

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