利用超高效液相色谱

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利用超高效液相色谱-四极杆飞行时间质谱法分析水产养殖水中的溴化物消毒副产物

IF 2.7 3区 化学 Q2 CHEMISTRY, ANALYTICAL

摘要

背景：事实证明，含卤消毒剂在水消毒过程中会产生有毒和致癌的消毒副产物（DBPs）。二溴海因（DBDMH）是水产养殖中常用的水消毒剂。水产养殖用水具有复杂的基质，但目前还没有关于测定其中所含 DBP 的分析方法的报道。DBP 的含量取决于紫外线照射、温度、pH 值和腐殖酸浓度等外部条件。利用超高效液相色谱-四极杆飞行时间质谱法（UPLC-Q-tof/MS），建立了基于质谱法生成的溴化物片段追踪和高分辨率质谱法精确测定其质量的 DBPs 半目标筛选方法。基于高分辨质谱法，开发了 Br-DBPs 的定量方法，Br-DBPs 是来自 DBDMH 的一类重要 DBPs。方法：通过筛选未知的 Br-DBPs 和对传统的 4-溴苯酚副产物进行定量分析，建立了精确的质量测定方法。对质谱仪的仪器参数和复杂实际样品的固相萃取进行了优化。在 0.500-200 μg/L 浓度范围内，该方法具有良好的线性相关（R2 = 0.999），检出限和定量限分别为 0.0250 ng/L 和 0.0834 ng/L。结果表明所建立的筛选和定量测定 Br-DBPs 的分析方法快速、准确、灵敏，适用于水产养殖用水的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Analysis of brominide disinfection by-products (DBPs) in aquaculture water using ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry (UPLC-Q-tof/MS)†

Background: halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products in the water disinfection process. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has more complex matrix, and the analytical method for disinfection by-products (DBPs) have not been reported. Since the content of DBPs is related to the external conditions such as ultraviolet irradiation, temperatures, pH and humic acid. The semi-target screening method for mainly DBPs based on tracing mass spectrometry fragments of bromide and accurate mass of high resolution mass spectrometry was established by ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-Q-tof/MS). Br-DBPs as a important class of DBPs from DBDMH, which quantification analysis methods were developed based on accurate mass of high resolution mass spectrometry. Methods: through screening method to identify unknown Br-DBPs and quantitative analysis of the typical 4-bromophenol by-product of accurate mass was established. The conditions of the instrument parameters of mass spectrometry and SPE sample preparation procedure in complex real sample were optimized. The high efficiency method was demonstrated for the determination of Br-DBPs with a good linear correlation (R2 = 0.999) in the range of 0.500–200 μg L−1 and limit of detections (LODs) and limit of quantifications (LOQs) were 0.0250 ng L−1 and 0.0834 ng L−1, respectively. Conclusion: the developed screening and quantification analytical strategy for Br-DBPs is rapid, accurate and sensitivity applicable for environmental in aquaculture water monitoring.

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