按需处方与持续处方质子泵抑制剂对症状负担和生活质量的影响：针对胃食管反

保持良好的睡眠习惯，睡眠质量对抑郁症有影响 #生活技巧# #心理健康建议# #抑郁症应对策略#

按需处方与持续处方质子泵抑制剂对症状负担和生活质量的影响：针对胃食管反流病患者的基层医疗机构真实世界随机对照试验结果。

Anna Andreasson, Lars Agréus, Nikolaos Mastellos, Grzegorz Bliźniuk, Dorota Waśko-Czopnik, Agapi Angelaki, Eirini Theodosaki, Christos Lionis, Karin Hek, Robert Verheij, Ellen Wright, Stevo Durbaba, Jean Muris, Piotr Bródka, Stanislaw Saganowski, Jean-Francois Ethiér, Vasa Curcin, Brendan Delaney

摘要

研究目的本研究旨在评估按需处方质子泵抑制剂（PPI）与持续处方质子泵抑制剂（PPI）对初级医疗机构胃食管反流病患者的症状负担和健康相关生活质量的影响：方法：欧洲 36 个初级保健中心从电子健康记录中登记了成年胃食管反流病患者。参与者被随机分配到按需或连续PPI处方，并接受为期8周的随访。采用混合效应回归分析比较了两组患者的 PPI 摄入量、症状负担和生活质量。斯皮尔曼相关性用于评估PPI剂量变化与患者报告结果之间的关联：共有 488 名患者（中位年龄 51 岁，58% 为女性）完成了初次就诊，其中 360 人参加了随访。连续处方组和按需处方组的 PPI 使用量无明显差异（b=.57，95%CI:0.40-1.53），但两组的 PPI 使用量均有所增加（b=1.33，95%CI:0.65-2.01）。处方策略建议对患者报告的结果没有明显影响。从基线到随访，两组患者的症状负担（反流病问卷，b=-0.61，95%CI：-0.73 --0.49）和生活质量（12项简表调查物理评分，b=3.31，95%CI：2.17 --4.45）均有所改善。PPI摄入量的增加与反流症状的减少（n = 347，ρ=-0.12，p = 0.02）和生活质量的改善（n = 217，ρ=0.16，p = 0.02）相关：结论：在现实世界中，连续处方和按需处方都会导致PPI用量的增加，但治疗效果并无差异。达到足够的PPI剂量以减轻反流症状负担可提高胃食管反流病患者的生活质量。EudraCT 编号 2014-001314-25。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effect of on-demand vs continuous prescription of proton pump inhibitors on symptom burden and quality of life: results of a real-world randomized controlled trial in primary care patients with gastroesophageal reflux disease.

Objectives: This study aimed to assess the impact of on-demand versus continuous prescribing of proton pump inhibitors (PPIs) on symptom burden and health-related quality of life in patients with gastroesophageal reflux disease (GERD) presenting to primary care.

Methods: Thirty-six primary care centres across Europe enrolled adult GERD patients from electronic health records. Participants were randomised to on-demand or continuous PPI prescriptions and were followed for 8 weeks. PPI intake, symptom burden, and quality of life were compared between the two groups using mixed-effect regression analyses. Spearman's correlation was used to assess the association between changes in PPI dose and patient-reported outcomes.

Results: A total of 488 patients (median age 51 years, 58% women) completed the initial visit, with 360 attending the follow-up visit. There was no significant difference in PPI use between the continuous and on-demand prescription groups (b=.57, 95%CI:0.40-1.53), although PPI use increased in both groups (b = 1.33, 95%CI:0.65 - 2.01). Advice on prescribing strategy did not significantly affect patient-reported outcomes. Both symptom burden (Reflux Disease Questionnaire, b=-0.61, 95%CI:-0.73 - -0.49) and quality of life (12-item Short Form Survey physical score b = 3.31, 95%CI:2.17 - 4.45) improved from baseline to follow-up in both groups. Increased PPI intake correlated with reduced reflux symptoms (n = 347, ρ=-0.12, p = 0.02) and improved quality of life (n = 217, ρ = 0.16, p = 0.02).

Conclusion: In real-world settings, both continuous and on-demand PPI prescriptions resulted in similar increases in PPI consumption with no difference in treatment effects. Achieving an adequate PPI dose to alleviate reflux symptom burden improves quality of life in GERD patients. EudraCT number 2014-001314-25.

相关文献

二甲双胍通过HDAC6和FoxO3a转录调控肌肉生长抑制素诱导肌肉萎缩

Min Ju Kang, Ji Wook Moon, Jung Ok Lee, Ji Hae Kim, Eun Jeong Jung, Su Jin Kim, Joo Yeon Oh, Sang Woo Wu, Pu Reum Lee, Sun Hwa Park, Hyeon Soo Kim

具有疾病敏感单倍型的非亲属供体脐带血移植后的1型糖尿病

Kensuke Matsumoto, Taisuke Matsuyama, Ritsu Sumiyoshi, Matsuo Takuji, Tadashi Yamamoto, Ryosuke Shirasaki, Haruko Tashiro

网址：按需处方与持续处方质子泵抑制剂对症状负担和生活质量的影响：针对胃食管反 https://www.yuejiaxmz.com/news/view/734317

相关内容

【中西合璧】针灸对胃癌辅助化疗患者生活质量的影响
食物营养与抑郁症——饮食与抑郁症
从心理学角度理解压力：症状和影响
抑郁症患者如何有效对抗持续性疲惫感
白色糠疹患者生活质量影响评估
脾胃虚寒的症状和调理
健康课堂之摩擦症如何影响生活质量改善策略一网打尽
生活方式及营养状况对老年骨质疏松患者疼痛的影响
健康指南房性早搏对运动和日常生活有影响吗
IJNS：渐进式肌肉放松训练对癌症相关疲劳和生活质量的影响@MedSci

随便看看